Assay Detail
Functional
CHEMBL844149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.28 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65030 | VAPIPROST | 2.0 | 1 | 7.92 |
| CHEMBL63056 | — | — | 1 | 7.75 |
| CHEMBL65414 | — | — | 1 | 7.75 |
| CHEMBL292331 | — | — | 2 | 7.66 |
| CHEMBL292740 | — | — | 1 | 7.62 |
| CHEMBL62834 | — | — | 1 | 7.34 |
| CHEMBL62852 | — | — | 1 | 7.24 |
| CHEMBL2115559 | — | — | 1 | 7.11 |
| CHEMBL2115518 | — | — | 1 | 6.98 |
| CHEMBL65161 | — | — | 1 | 6.64 |
| CHEMBL48092 | PIRMAGREL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65030 | VAPIPROST | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL63056 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL65414 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL292331 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL292740 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL62834 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL62852 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2115559 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2115518 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL65161 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL292331 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL48092 | PIRMAGREL | IC50 | - | nM | - |