Assay Detail
Binding
CHEMBL844164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thymidylate synthase from L1210 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169981 | — | — | 1 | 7.70 |
| CHEMBL434209 | — | — | 1 | 7.40 |
| CHEMBL75291 | — | — | 1 | 7.10 |
| CHEMBL307914 | — | — | 1 | 6.92 |
| CHEMBL40321 | — | — | 1 | 6.52 |
| CHEMBL73902 | — | — | 1 | 6.22 |
| CHEMBL420935 | — | — | 1 | 6.02 |
| CHEMBL77314 | — | — | 1 | 6.00 |
| CHEMBL419092 | — | — | 1 | 5.96 |
| CHEMBL73971 | — | — | 1 | 5.94 |
| CHEMBL307399 | — | — | 1 | 5.84 |
| CHEMBL420204 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169981 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL434209 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL75291 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL307914 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL40321 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL73902 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL420935 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL77314 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL419092 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL73971 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL307399 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL420204 | — | IC50 | = | 1700.0 | nM | 5.77 |