Assay Detail
Functional
CHEMBL844180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.02 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94124 | HYDROXYPHENSTATIN | — | 1 | 6.09 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL36255 | COMBRETASTATIN A-1 | 1.0 | 1 | 5.96 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | - |
| CHEMBL329267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94124 | HYDROXYPHENSTATIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL36255 | COMBRETASTATIN A-1 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | > | 40000.0 | nM | - |
| CHEMBL329267 | — | IC50 | > | 40000.0 | nM | - |