Assay Detail
Binding
CHEMBL844214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for mu opioid receptor was evaluated by displacing [3H]- diprenorphine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.34 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.44 |
| CHEMBL55033 | — | — | 1 | 6.16 |
| CHEMBL607263 | — | — | 1 | 6.08 |
| CHEMBL290543 | — | — | 1 | 5.67 |
| CHEMBL293135 | — | — | 1 | - |
| CHEMBL301066 | — | — | 1 | - |
| CHEMBL53216 | — | — | 1 | - |
| CHEMBL52307 | — | — | 1 | - |
| CHEMBL54780 | — | — | 1 | - |
| CHEMBL54329 | — | — | 1 | - |
| CHEMBL54581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL55033 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL607263 | — | Ki | = | 825.0 | nM | 6.08 |
| CHEMBL290543 | — | Ki | = | 2128.0 | nM | 5.67 |
| CHEMBL293135 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL301066 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL53216 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL52307 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL54780 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL54329 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL54581 | — | Ki | > | 25000.0 | nM | - |