Assay Detail
Binding
CHEMBL844217
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Compound was tested for binding affinity towards mu-opioid receptor in rat forebrain membrane using [3H]DAMGO
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.80 | 9.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415330 | — | — | 1 | 9.71 |
| CHEMBL404976 | — | — | 1 | 8.00 |
| CHEMBL2369477 | — | — | 2 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415330 | — | Ki | = | 0.194 | nM | 9.71 |
| CHEMBL404976 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2369477 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL2369477 | — | Ki | = | 275.0 | nM | 6.56 |