Assay Detail
Binding
CHEMBL844336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against bovine trypsin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.57 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20240 | YM-60828 | — | 1 | 6.80 |
| CHEMBL19902 | DX-9065A | — | 1 | 6.20 |
| CHEMBL283765 | — | — | 1 | 6.01 |
| CHEMBL20733 | — | — | 1 | 5.80 |
| CHEMBL20672 | — | — | 1 | 5.77 |
| CHEMBL417827 | — | — | 1 | 5.13 |
| CHEMBL20825 | — | — | 1 | 4.90 |
| CHEMBL20912 | — | — | 1 | 4.85 |
| CHEMBL20936 | BENZAMIDINE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20240 | YM-60828 | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL19902 | DX-9065A | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL283765 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL20733 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL20672 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL417827 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL20825 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL20912 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 20000.0 | nM | 4.70 |