Assay Detail
Functional
CHEMBL844576
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Vasorelaxant effect on KCl-Induced contraction of rat aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and selective coronary vasodilatory activity of 3,4-dihydro-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol derivatives: novel potassium channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.60 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.44 |
| CHEMBL100 | LEVCROMAKALIM | 2.0 | 1 | 6.54 |
| CHEMBL288989 | — | — | 1 | 6.52 |
| CHEMBL284906 | NICORANDIL | 3.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL100 | LEVCROMAKALIM | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL288989 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL284906 | NICORANDIL | IC50 | = | 13000.0 | nM | 4.89 |