Assay Detail
Functional
CHEMBL844795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antiherpesvirus activity against vero cells infected with HSV-2(G strain)[plaque reduction assay]
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.73 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223737 | GS-438 | -1.0 | 1 | 5.96 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.92 |
| CHEMBL91794 | — | — | 1 | 4.37 |
| CHEMBL92761 | — | — | 1 | 4.09 |
| CHEMBL92289 | — | — | 1 | 4.01 |
| CHEMBL419692 | — | — | 1 | 4.00 |
| CHEMBL99758 | — | — | 1 | - |
| CHEMBL100537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223737 | GS-438 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL91794 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL92761 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL92289 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL419692 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL99758 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL100537 | — | IC50 | > | 300000.0 | nM | - |