Assay Detail
Binding
CHEMBL844877
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Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumna
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.55 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332005 | — | — | 2 | 6.73 |
| CHEMBL124527 | — | — | 1 | 6.50 |
| CHEMBL332012 | — | — | 1 | 5.30 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | — | 1 | 5.29 |
| CHEMBL125345 | — | — | 1 | 4.88 |
| CHEMBL420149 | — | — | 1 | 4.47 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | 4.47 |
| CHEMBL72628 | 2-PICOLINIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332005 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL332005 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL124527 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL332012 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL125345 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL420149 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL39879 | DIPYRIDYL | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL72628 | 2-PICOLINIC ACID | IC50 | = | 111500.0 | nM | - |