Compound Detail
CHEMBL125345
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Basic Information
| ChEMBL ID | CHEMBL125345 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WNPCDCLCWAAEPZ-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1205641 |
| Active Moiety | CHEMBL1205641 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
1
Known Names
Molecular Properties
200.2
MW (Da)
1.84
ALogP
3
HBA
1
HBD
63.1
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transmembrane prolyl 4-hydroxylase CHEMBL3047 | IC50 | 4.88 | 4.88 | 13200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transmembrane prolyl 4-hydroxylase | IC50 | = | 13200.0 | nM | 4.88 | Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-suc... | 8254616 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8254616 | 10.1021/jm00076a014 | Transmembrane prolyl 4-hydroxylase | 1 |
Data from ChEMBL 36 via Core Engine