Assay Detail
Binding
CHEMBL844880
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Aminoacylation activity against Candida albicans prolyl-tRNA synthetase
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proline--tRNA ligase, cytoplasmic (CHEMBL4636) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans |
Publication
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.35 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357355 | — | — | 1 | 8.30 |
| CHEMBL357572 | — | — | 1 | 7.72 |
| CHEMBL345331 | — | — | 1 | 7.70 |
| CHEMBL153347 | — | — | 1 | 7.60 |
| CHEMBL150488 | — | — | 1 | 7.60 |
| CHEMBL153238 | — | — | 1 | 7.58 |
| CHEMBL151039 | — | — | 1 | 7.52 |
| CHEMBL153295 | — | — | 1 | 7.28 |
| CHEMBL150266 | — | — | 1 | 7.16 |
| CHEMBL346646 | — | — | 1 | 6.92 |
| CHEMBL358675 | — | — | 1 | 6.85 |
| CHEMBL348184 | — | — | 1 | 6.82 |
| CHEMBL149973 | — | — | 1 | 6.66 |
| CHEMBL150896 | — | — | 1 | 6.46 |
| CHEMBL440534 | — | — | 1 | 6.30 |
| CHEMBL150306 | — | — | 1 | 5.89 |
| CHEMBL150407 | — | — | 1 | 5.82 |
| CHEMBL151769 | — | — | 1 | 5.82 |
| CHEMBL150305 | — | — | 1 | 5.62 |
| CHEMBL356452 | — | — | 1 | 5.48 |
| CHEMBL345300 | — | — | 1 | 5.44 |
| CHEMBL434852 | — | — | 1 | 5.24 |
| CHEMBL153564 | — | — | 1 | 5.06 |
| CHEMBL153066 | — | — | 1 | 4.82 |
| CHEMBL150249 | — | — | 1 | 4.72 |
| CHEMBL150993 | — | — | 1 | 4.60 |
| CHEMBL153072 | — | — | 1 | 4.50 |
| CHEMBL150924 | — | — | 1 | - |
| CHEMBL348000 | CINCHOPHEN | 4.0 | 1 | - |
| CHEMBL415737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357355 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL357572 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL345331 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL153347 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL150488 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL153238 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL151039 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL153295 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL150266 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL346646 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL358675 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL348184 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL149973 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL150896 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL440534 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL150306 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL150407 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL151769 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL150305 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL356452 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL345300 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL434852 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL153564 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL153066 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL150249 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL150993 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL153072 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL150924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348000 | CINCHOPHEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL415737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL149961 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151890 | — | IC50 | > | 100000.0 | nM | - |