Assay Detail
Functional
CHEMBL844936
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Ability to inhibit the release of tumor necrosis factor alpha (TNF-alpha) from whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Imidazole inhibitors of cytokine release: probing substituents in the 2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.93 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.03 |
| CHEMBL113419 | — | — | 1 | 5.38 |
| CHEMBL142841 | — | — | 1 | 5.05 |
| CHEMBL111456 | — | — | 1 | 4.69 |
| CHEMBL143482 | — | — | 1 | 4.54 |
| CHEMBL143370 | — | — | 1 | 4.47 |
| CHEMBL358814 | — | — | 1 | 4.32 |
| CHEMBL142571 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL113419 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL142841 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL111456 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL143482 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL143370 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL358814 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL142571 | — | IC50 | = | 103000.0 | nM | - |