Assay Detail
Binding
CHEMBL845034
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Inhibition of human thrombin by chromogenic assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of novel potent nonpeptide thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.61 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48635 | — | — | 1 | 8.27 |
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 8.03 |
| CHEMBL49445 | — | — | 1 | 8.00 |
| CHEMBL48914 | — | — | 1 | 8.00 |
| CHEMBL298500 | — | — | 1 | 7.96 |
| CHEMBL417360 | — | — | 1 | 7.50 |
| CHEMBL299515 | — | — | 1 | 7.27 |
| CHEMBL51528 | — | — | 1 | 7.24 |
| CHEMBL46434 | — | — | 1 | 6.92 |
| CHEMBL299580 | — | — | 1 | 6.89 |
| CHEMBL51173 | — | — | 1 | 6.70 |
| CHEMBL424593 | — | — | 1 | 6.58 |
| CHEMBL49216 | — | — | 1 | 6.48 |
| CHEMBL51050 | — | — | 1 | 6.29 |
| CHEMBL300305 | — | — | 1 | 6.22 |
| CHEMBL50790 | — | — | 1 | 5.89 |
| CHEMBL46780 | — | — | 1 | 5.82 |
| CHEMBL299743 | — | — | 1 | 5.80 |
| CHEMBL300937 | — | — | 1 | 5.75 |
| CHEMBL48882 | — | — | 1 | 5.62 |
| CHEMBL48517 | — | — | 1 | 5.40 |
| CHEMBL49181 | — | — | 1 | 4.72 |
| CHEMBL298578 | — | — | 1 | 4.62 |
| CHEMBL48717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48635 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL48361 | DABIGATRAN | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL49445 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL48914 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL298500 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL417360 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL299515 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL51528 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL46434 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL299580 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL51173 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL424593 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL49216 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL51050 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL300305 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL50790 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL46780 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL299743 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL300937 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL48882 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL48517 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL49181 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL298578 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL48717 | — | IC50 | > | 100000.0 | nM | - |