Assay Detail
Binding
CHEMBL845035
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Inhibitory activity against human thrombin was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.64 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140247 | — | — | 1 | 8.05 |
| CHEMBL344896 | — | — | 1 | 7.11 |
| CHEMBL337572 | — | — | 1 | 6.89 |
| CHEMBL136980 | — | — | 1 | 6.22 |
| CHEMBL337306 | — | — | 1 | 5.80 |
| CHEMBL344421 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140247 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL344896 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL337572 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL136980 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL337306 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL344421 | — | IC50 | = | 1800.0 | nM | 5.75 |