Assay Detail
Functional
CHEMBL845194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound against GnRH stimulated calcium flux in transfected cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324912 | — | — | 1 | 7.70 |
| CHEMBL326504 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324912 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL326504 | — | IC50 | = | 60.0 | nM | 7.22 |