Assay Detail
Functional
CHEMBL845250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration needed to inhibit tubulin polymerization by 50%
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.43 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45512 | — | — | 1 | 6.17 |
| CHEMBL297848 | — | — | 1 | 6.14 |
| CHEMBL297677 | — | — | 1 | 6.10 |
| CHEMBL296066 | — | — | 1 | 6.06 |
| CHEMBL46052 | — | — | 1 | 6.04 |
| CHEMBL45473 | — | — | 1 | 6.01 |
| CHEMBL295738 | — | — | 1 | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL47306 | — | — | 1 | 5.75 |
| CHEMBL295644 | — | — | 1 | 5.70 |
| CHEMBL296914 | — | — | 1 | 5.55 |
| CHEMBL296406 | — | — | 1 | 5.43 |
| CHEMBL46072 | — | — | 1 | 5.12 |
| CHEMBL45481 | — | — | 1 | 5.11 |
| CHEMBL297236 | — | — | 1 | 4.64 |
| CHEMBL46215 | — | — | 1 | 4.51 |
| CHEMBL47112 | — | — | 1 | 4.46 |
| CHEMBL45469 | — | — | 1 | 4.32 |
| CHEMBL48004 | — | — | 1 | 4.15 |
| CHEMBL297018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45512 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL297848 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL297677 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL296066 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL46052 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL45473 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL295738 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL47306 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL295644 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL296914 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL296406 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL46072 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL45481 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL297236 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL46215 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL47112 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL45469 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL48004 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL297018 | — | IC50 | = | 130000.0 | nM | - |