Assay Detail
Functional
CHEMBL845862
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Intrinsic activity which is established by measuring the stimulation of mitogenesis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.00 |
| CHEMBL7927 | FAUC 113 | — | 1 | 7.92 |
| CHEMBL432059 | — | — | 1 | 7.62 |
| CHEMBL430832 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7927 | FAUC 113 | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL432059 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL430832 | — | EC50 | = | 31.0 | nM | 7.51 |