Assay Detail
Binding
CHEMBL846286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.18 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.70 |
| CHEMBL345472 | — | — | 1 | 7.72 |
| CHEMBL2093042 | — | — | 1 | 7.72 |
| CHEMBL346083 | — | — | 1 | 7.68 |
| CHEMBL158977 | — | — | 1 | 7.65 |
| CHEMBL158487 | — | — | 1 | 7.62 |
| CHEMBL160185 | — | — | 1 | 7.61 |
| CHEMBL160463 | — | — | 1 | 7.55 |
| CHEMBL158644 | — | — | 1 | 7.52 |
| CHEMBL160603 | — | — | 1 | 7.44 |
| CHEMBL350482 | — | — | 1 | 7.41 |
| CHEMBL345877 | — | — | 1 | 7.25 |
| CHEMBL1788264 | — | — | 1 | 7.24 |
| CHEMBL158616 | — | — | 1 | 7.17 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.15 |
| CHEMBL434092 | — | — | 1 | 7.07 |
| CHEMBL345418 | — | — | 1 | 6.96 |
| CHEMBL160144 | — | — | 1 | 6.71 |
| CHEMBL160360 | — | — | 1 | 6.62 |
| CHEMBL345210 | — | — | 1 | 6.56 |
| CHEMBL346946 | — | — | 1 | 6.49 |
| CHEMBL158431 | — | — | 1 | 6.47 |
| CHEMBL157535 | — | — | 1 | 6.43 |
| CHEMBL345167 | — | — | 1 | 6.40 |
| CHEMBL352245 | — | — | 1 | 6.31 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.13 |
| CHEMBL158982 | — | — | 1 | - |
| CHEMBL157812 | — | — | 1 | - |
| CHEMBL349333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL345472 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2093042 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL346083 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL158977 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL158487 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL160185 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL160463 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL158644 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL160603 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL350482 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL345877 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL1788264 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL158616 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL434092 | — | IC50 | = | 85.8 | nM | 7.07 |
| CHEMBL345418 | — | IC50 | = | 109.6 | nM | 6.96 |
| CHEMBL160144 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL160360 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL345210 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL346946 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL158431 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL157535 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL345167 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL352245 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL158982 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL157812 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL349333 | — | IC50 | > | 1000.0 | nM | - |