Assay Detail
Binding
CHEMBL846287
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Inhibition of phosphodiesterase 3
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Stereoselectivity of the positive inotropic effects of newer diazinone-cardiotonics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.32 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2051955 | LEVOSIMENDAN | 3.0 | 1 | 8.10 |
| CHEMBL85074 | MERIBENDAN | 2.0 | 2 | 7.40 |
| CHEMBL314612 | — | — | 2 | 7.30 |
| CHEMBL86331 | — | — | 2 | 7.10 |
| CHEMBL24646 | PIMOBENDAN | 2.0 | 2 | 6.39 |
| CHEMBL313136 | SIMENDAN | 2.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2051955 | LEVOSIMENDAN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL85074 | MERIBENDAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL314612 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL86331 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL24646 | PIMOBENDAN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL313136 | SIMENDAN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL85074 | MERIBENDAN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL314612 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL86331 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL24646 | PIMOBENDAN | IC50 | = | 19000.0 | nM | 4.72 |