Compound Detail
CHEMBL85074
MERIBENDAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL85074 |
| Name | MERIBENDAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FDWDHUONLKCDBV-UHFFFAOYSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
1
Known Names
Molecular Properties
294.3
MW (Da)
1.81
ALogP
4
HBA
3
HBD
98.8
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
EC50 2 meas.
IC50 2 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 7.4 | 6.6 | 40.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 3 | IC50 | = | 40.0 | nM | 7.4 | Inhibition of phosphodiesterase 3 | - |
| Phosphodiesterase 3 | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of phosphodiesterase 3 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80288-2 | NON-PROTEIN TARGET | 2 |
| - | 10.1016/S0960-894X(01)80288-2 | Phosphodiesterase 3 | 2 |
Data from ChEMBL 36 via Core Engine