Assay Detail
Binding
CHEMBL846736
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In vitro for its binding affinity to rat V2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and vasopressin (AVP) antagonist activity of a novel series of N-aroyl-2,4,5,6-tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.24 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162748 | — | — | 1 | 8.22 |
| CHEMBL351970 | — | — | 1 | 7.44 |
| CHEMBL350090 | — | — | 1 | 7.16 |
| CHEMBL350383 | — | — | 1 | 6.92 |
| CHEMBL162588 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162748 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL351970 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL350090 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL350383 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL162588 | — | IC50 | = | 340.0 | nM | 6.47 |