Assay Detail
Functional
CHEMBL846763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effect on production of calcium ionophore (A23187) -induced Leukotriene B4 (LTB4) in rat peritoneal cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62990 | — | — | 1 | 6.10 |
| CHEMBL64507 | — | — | 1 | 5.82 |
| CHEMBL294100 | — | — | 1 | 5.75 |
| CHEMBL65325 | — | — | 1 | 5.75 |
| CHEMBL62920 | — | — | 1 | 5.72 |
| CHEMBL305076 | — | — | 1 | 5.60 |
| CHEMBL291543 | — | — | 1 | 5.60 |
| CHEMBL60725 | — | — | 1 | 5.55 |
| CHEMBL303092 | — | — | 1 | 5.52 |
| CHEMBL60496 | — | — | 1 | 5.50 |
| CHEMBL65140 | — | — | 1 | 5.31 |
| CHEMBL65330 | — | — | 1 | 5.22 |
| CHEMBL60738 | — | — | 1 | 5.02 |
| CHEMBL62439 | — | — | 1 | 4.68 |
| CHEMBL60793 | — | — | 1 | 4.55 |
| CHEMBL1908355 | TENIDAP | 2.0 | 1 | 4.35 |
| CHEMBL64813 | — | — | 1 | 4.13 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL64585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62990 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL64507 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL294100 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL65325 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL62920 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL305076 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL291543 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL60725 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL303092 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL60496 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL65140 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL65330 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL60738 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL62439 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL60793 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1908355 | TENIDAP | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL64813 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL64585 | — | IC50 | > | 100000.0 | nM | - |