Assay Detail

CHEMBL846889

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Tested for inhibition of CA1 population spike in rat hippocampal slice by electrophysiological experiment

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Rattus norvegicus (CHEMBL376) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Rattus norvegicus (CHEMBL376) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rattus norvegicus

CHEMBL376

Anchored from Assay target.

Protein identity Rattus norvegicus

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Hippocampus
Confidence	1 — Organism
Curated By	Intermediate

Target

Rattus norvegicus (CHEMBL376) ↗

Type	ORGANISM
Organism	Rattus norvegicus

Publication

()-2-amino-2-thiazoline-4-ethanoic acid; a novel, specific GABAA receptor agonist

Campbell M, Mickel S, Singh G
Bioorg Med Chem Lett (1991) 1 : 247 -248
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	4.58	4.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39071	ISOGUVACINE	—	1	4.89
CHEMBL312443	GABOXADOL	3.0	1	4.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39071	ISOGUVACINE	EC50	=	13000.0	nM	4.89
CHEMBL312443	GABOXADOL	EC50	=	55000.0	nM	4.26