Assay Detail
Binding
CHEMBL846955
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Inhibition of phosphomannose isomerase enzyme of Candida albicans (CaPMI)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Mannose-6-phosphate isomerase (CHEMBL3946) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.54 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75413 | — | — | 1 | 5.22 |
| CHEMBL74105 | — | — | 1 | 4.85 |
| CHEMBL75418 | — | — | 1 | 4.82 |
| CHEMBL75202 | — | — | 1 | 4.68 |
| CHEMBL75281 | — | — | 1 | 4.52 |
| CHEMBL76057 | — | — | 1 | 4.47 |
| CHEMBL72323 | — | — | 1 | 4.47 |
| CHEMBL75654 | — | — | 1 | 4.41 |
| CHEMBL75655 | — | — | 1 | 4.40 |
| CHEMBL311282 | — | — | 1 | 4.30 |
| CHEMBL306106 | — | — | 1 | 4.30 |
| CHEMBL305894 | — | — | 1 | 4.03 |
| CHEMBL72383 | — | — | 1 | - |
| CHEMBL76042 | — | — | 1 | - |
| CHEMBL77470 | — | — | 1 | - |
| CHEMBL76058 | — | — | 1 | - |
| CHEMBL75028 | — | — | 1 | - |
| CHEMBL75415 | — | — | 1 | - |
| CHEMBL77802 | — | — | 1 | - |
| CHEMBL308117 | — | — | 1 | - |
| CHEMBL306795 | — | — | 1 | - |
| CHEMBL421692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75413 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL74105 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL75418 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL75202 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL75281 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL76057 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL72323 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL75654 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL75655 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL311282 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL306106 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL305894 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL72383 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL76042 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL77470 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL76058 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL75028 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL75415 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL77802 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL308117 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL306795 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL421692 | — | IC50 | > | 500000.0 | nM | - |