Assay Detail
Binding
CHEMBL847103
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Binding affinity for Plasmodium falciparum plasmepsin-2.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.79 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113208 | — | — | 1 | 9.25 |
| CHEMBL33989 | — | — | 1 | 8.37 |
| CHEMBL115048 | — | — | 1 | 7.30 |
| CHEMBL353118 | — | — | 1 | 6.93 |
| CHEMBL163104 | — | — | 1 | 6.92 |
| CHEMBL162454 | — | — | 1 | 6.89 |
| CHEMBL162554 | — | — | 1 | 6.82 |
| CHEMBL349737 | — | — | 1 | 6.42 |
| CHEMBL163249 | — | — | 1 | 6.27 |
| CHEMBL434853 | — | — | 1 | 6.24 |
| CHEMBL162495 | — | — | 1 | 6.03 |
| CHEMBL351939 | — | — | 1 | 6.03 |
| CHEMBL349736 | — | — | 1 | 5.84 |
| CHEMBL349421 | — | — | 1 | 5.72 |
| CHEMBL163085 | — | — | 1 | - |
| CHEMBL436438 | — | — | 1 | - |
| CHEMBL162362 | — | — | 1 | - |
| CHEMBL350081 | — | — | 1 | - |
| CHEMBL353782 | — | — | 1 | - |
| CHEMBL163038 | — | — | 1 | - |
| CHEMBL162898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113208 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL33989 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL115048 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL353118 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL163104 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL162454 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL162554 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL349737 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL163249 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL434853 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL162495 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL351939 | — | Ki | = | 928.0 | nM | 6.03 |
| CHEMBL349736 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL349421 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL163085 | — | Ki | ~ | 3500.0 | nM | - |
| CHEMBL436438 | — | Ki | ~ | 3300.0 | nM | - |
| CHEMBL162362 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL350081 | — | Ki | ~ | 3200.0 | nM | - |
| CHEMBL353782 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL163038 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL162898 | — | Ki | > | 2000.0 | nM | - |