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Assay Detail

CHEMBL847140

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Binding
Tested in vitro for inhibition of serine/threonine kinase Cdc2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cyclin-dependent kinase 1 (CHEMBL308)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Missbach M, Altmann E, Widler L, Susa M, Buchdunger E, Mett H, Meyer T, Green J.
Bioorg Med Chem Lett (2000) 10 : 945 -949
PubMed 10853665 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.30 4.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367442 1 4.52
CHEMBL176815 1 4.48
CHEMBL172973 1 4.37
CHEMBL173478 1 4.33
CHEMBL169757 1 4.27
CHEMBL173453 1 4.08
CHEMBL174634 1 4.05
CHEMBL429057 1 -
CHEMBL366831 1 -
CHEMBL424375 1 -
CHEMBL176702 1 -
CHEMBL175409 1 -
CHEMBL105436 1 -
CHEMBL176705 1 -
CHEMBL369014 1 -
CHEMBL176309 1 -
CHEMBL176470 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367442 IC50 = 30000.0 nM 4.52
CHEMBL176815 IC50 = 33000.0 nM 4.48
CHEMBL172973 IC50 = 43000.0 nM 4.37
CHEMBL173478 IC50 = 47000.0 nM 4.33
CHEMBL169757 IC50 = 54000.0 nM 4.27
CHEMBL173453 IC50 = 82500.0 nM 4.08
CHEMBL174634 IC50 = 90000.0 nM 4.05
CHEMBL429057 IC50 > 10000.0 nM -
CHEMBL366831 IC50 > 10000.0 nM -
CHEMBL424375 IC50 > 10000.0 nM -
CHEMBL176702 IC50 > 10000.0 nM -
CHEMBL175409 IC50 > 10000.0 nM -
CHEMBL105436 IC50 > 10000.0 nM -
CHEMBL176705 IC50 > 10000.0 nM -
CHEMBL369014 IC50 > 10000.0 nM -
CHEMBL176309 IC50 > 100000.0 nM -
CHEMBL176470 IC50 > 10000.0 nM -