Compound Detail
CHEMBL366831
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Basic Information
| ChEMBL ID | CHEMBL366831 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUCUUSDIHUJLCZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
300.4
MW (Da)
4.13
ALogP
4
HBA
1
HBD
42.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of c-Src | 18722033 |
| Epidermal growth factor receptor | IC50 | = | 31000.0 | nM | 4.51 | Tested in vitro for inhibition of EGF-receptor tyrosine kinase | 10853665 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10853665 | 10.1016/s0960-894x(00)00131-1 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 10853665 | 10.1016/s0960-894x(00)00131-1 | Epidermal growth factor receptor | 1 |
| 10853665 | 10.1016/s0960-894x(00)00131-1 | Vascular endothelial growth factor receptor 2 | 1 |
| 10853665 | 10.1016/s0960-894x(00)00131-1 | Tyrosine-protein kinase ABL | 1 |
| 10853665 | 10.1016/s0960-894x(00)00131-1 | Cyclin-dependent kinase 1 | 1 |
| 18722033 | 10.1016/j.ejmech.2008.07.002 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine