Assay Detail
Binding
CHEMBL847455
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In vitro inhibitory activity against thrombin(FIIa)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.58 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333154 | — | — | 1 | 9.00 |
| CHEMBL324413 | — | — | 1 | 8.30 |
| CHEMBL332716 | — | — | 1 | 7.52 |
| CHEMBL3349354 | — | — | 1 | 7.48 |
| CHEMBL115294 | — | — | 1 | 7.11 |
| CHEMBL116297 | — | — | 1 | 6.86 |
| CHEMBL115236 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333154 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL324413 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL332716 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3349354 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL115294 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL116297 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL115236 | — | IC50 | = | 150.0 | nM | 6.82 |