Assay Detail
Functional
CHEMBL847558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpressing the human VR1
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 8.13 | 9.40 |
| Log EC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124602 | — | — | 1 | 9.40 |
| CHEMBL121808 | — | — | 1 | 9.30 |
| CHEMBL123254 | — | — | 1 | 9.30 |
| CHEMBL76903 | OLVANIL | 2.0 | 1 | 9.30 |
| CHEMBL122864 | — | — | 1 | 8.90 |
| CHEMBL124002 | — | — | 1 | 8.90 |
| CHEMBL333489 | — | — | 1 | 8.80 |
| CHEMBL313885 | — | — | 1 | 8.70 |
| CHEMBL124415 | — | — | 1 | 8.70 |
| CHEMBL332105 | — | — | 1 | 8.60 |
| CHEMBL126095 | — | — | 1 | 8.50 |
| CHEMBL122849 | — | — | 1 | 8.50 |
| CHEMBL121925 | — | — | 1 | 8.50 |
| CHEMBL124163 | — | — | 1 | 8.40 |
| CHEMBL126172 | — | — | 1 | 8.30 |
| CHEMBL124613 | — | — | 1 | 8.30 |
| CHEMBL122156 | — | — | 1 | 8.20 |
| CHEMBL121730 | — | — | 1 | 7.90 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.70 |
| CHEMBL121867 | — | — | 1 | 7.40 |
| CHEMBL122039 | — | — | 1 | 7.10 |
| CHEMBL125758 | — | — | 1 | 6.90 |
| CHEMBL124721 | — | — | 1 | 6.70 |
| CHEMBL122560 | — | — | 1 | 6.70 |
| CHEMBL122911 | — | — | 1 | 6.30 |
| CHEMBL123157 | — | — | 1 | 6.10 |
| CHEMBL78533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124602 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL121808 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL123254 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL76903 | OLVANIL | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL122864 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL124002 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL333489 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL313885 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL124415 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL332105 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL126095 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL122849 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL121925 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL124163 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL126172 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL124613 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL122156 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL121730 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL121867 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL122039 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL125758 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL124721 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL122560 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL122911 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL123157 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL78533 | — | Log EC50 | = | - | — | - |