Assay Detail
Binding
CHEMBL847682
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Inhibition of tie-2 at 5 uM ATP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.80 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69129 | — | — | 1 | 7.23 |
| CHEMBL69827 | — | — | 1 | 6.82 |
| CHEMBL307982 | — | — | 1 | 6.37 |
| CHEMBL419082 | — | — | 1 | 6.22 |
| CHEMBL47940 | — | — | 1 | 5.70 |
| CHEMBL302281 | — | — | 1 | 5.57 |
| CHEMBL69638 | — | — | 1 | 5.47 |
| CHEMBL68774 | — | — | 1 | 5.31 |
| CHEMBL306380 | — | — | 1 | 5.16 |
| CHEMBL306012 | — | — | 1 | 5.16 |
| CHEMBL304760 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69129 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL69827 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL307982 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL419082 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL47940 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL302281 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL69638 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL68774 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL306380 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL306012 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL304760 | — | IC50 | = | 17870.0 | nM | 4.75 |