Assay Detail
Functional
CHEMBL847711
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Dose inhibiting the twitch response induced by hCGRP-alpha in rat vas deferens.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.53 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369459 | — | — | 1 | 8.85 |
| CHEMBL2369464 | — | — | 1 | 8.85 |
| CHEMBL2369457 | — | — | 1 | 8.66 |
| CHEMBL2369458 | — | — | 1 | 8.62 |
| CHEMBL2369465 | — | — | 1 | 8.51 |
| CHEMBL2369452 | — | — | 1 | 8.49 |
| CHEMBL2369454 | — | — | 1 | 8.49 |
| CHEMBL525571 | — | — | 1 | 8.17 |
| CHEMBL2369463 | — | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369459 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2369464 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2369457 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2369458 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2369465 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2369452 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2369454 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL525571 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2369463 | — | EC50 | = | 7.6 | nM | 8.12 |