Assay Detail
Binding
CHEMBL847893
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Activation of bovine sGC Enzyme (soluble Guanylate Cyclase) in Sf21 cells infected with baculo virus in the presence of 30 nM of PAPA/NO
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf21 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.13 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366876 | — | — | 1 | 6.78 |
| CHEMBL427292 | — | — | 1 | 6.36 |
| CHEMBL174528 | — | — | 1 | 6.24 |
| CHEMBL174032 | — | — | 1 | 6.14 |
| CHEMBL12610 | BENZYDAMINE | 3.0 | 1 | 5.99 |
| CHEMBL12609 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366876 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL427292 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL174528 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL174032 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL12610 | BENZYDAMINE | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL12609 | — | EC50 | = | 5490.0 | nM | 5.26 |