Compound Detail
CHEMBL12610
BENZYDAMINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL12610 |
| Name | BENZYDAMINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | CNBGNNVCVSKAQZ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
3
Activities
2
Assay Types
4
PK Parameters
20
Publications
4
Known Names
5
Indications
1
Mechanisms
Molecular Properties
309.4
MW (Da)
3.42
ALogP
4
HBA
0
HBD
30.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cyclooxygenase inhibitor | INHIBITOR | Cyclooxygenase | ✓ | ✓ |
Indications
Arthralgia Myalgia Rheumatic Diseases Vaginitis Stomatitis
ATC Classification
A01AD02
benzydamine
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: STOMATOLOGICAL PREPARATIONS
G02CC03
benzydamine
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: OTHER GYNECOLOGICALS
M01AX07
benzydamine
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M02AA05
benzydamine
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
R02AX03
benzydamine
Level 1: RESPIRATORY SYSTEM
Level 2: THROAT PREPARATIONS
Activity Summary
EC50 2 meas. best 5.99
IC50 1 meas. best 5.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Soluble guanylate cyclase CHEMBL2111348 | EC50 | 5.99 | 5.99 | 1020.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.99 | 5.99 | 1020.0 | 1 |
| Homo sapiens CHEMBL372 | IC50 | 5.18 | 5.18 | 6670.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 7.76 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 17.78 | mL.min-1.g-1 | Homo sapiens |
| CL | 150.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| T1/2 | 0.7183 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Soluble guanylate cyclase | EC50 | = | 1020.0 | nM | 5.99 | The cGMP produced by compound was expressed as a ratio between the percentage of... | 11327597 |
| Unchecked | EC50 | = | 1020.0 | nM | 5.99 | Activation of bovine sGC Enzyme (soluble Guanylate Cyclase) in Sf21 cells infect... | 11141091 |
| Homo sapiens | IC50 | = | 6670.0 | nM | 5.18 | Concentration required to inhibit collagen-induced platelet aggregation by 50% | 11141091 |
Literature References
Data from ChEMBL 36 via Core Engine