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Assay Detail

CHEMBL696984

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit collagen-induced platelet aggregation by 50%
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK.
J Med Chem (2001) 44 : 78 -93
PubMed 11141091 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.03 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL427292 1 5.62
CHEMBL172329 1 5.61
CHEMBL174528 1 5.55
CHEMBL12609 1 5.55
CHEMBL173621 1 5.38
CHEMBL12610 BENZYDAMINE 3.0 1 5.18
CHEMBL436280 1 5.12
CHEMBL176646 1 5.07
CHEMBL173573 1 4.92
CHEMBL176902 1 4.67
CHEMBL174295 1 4.39
CHEMBL366876 1 4.31
CHEMBL173268 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL427292 IC50 = 2370.0 nM 5.62
CHEMBL172329 IC50 = 2460.0 nM 5.61
CHEMBL174528 IC50 = 2840.0 nM 5.55
CHEMBL12609 IC50 = 2840.0 nM 5.55
CHEMBL173621 IC50 = 4180.0 nM 5.38
CHEMBL12610 BENZYDAMINE IC50 = 6670.0 nM 5.18
CHEMBL436280 IC50 = 7620.0 nM 5.12
CHEMBL176646 IC50 = 8570.0 nM 5.07
CHEMBL173573 IC50 = 12040.0 nM 4.92
CHEMBL176902 IC50 = 21600.0 nM 4.67
CHEMBL174295 IC50 = 41120.0 nM 4.39
CHEMBL366876 IC50 = 49200.0 nM 4.31
CHEMBL173268 IC50 = 99000.0 nM 4.00