Assay Detail
Functional
CHEMBL848083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.11 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287169 | — | — | 1 | 8.34 |
| CHEMBL285368 | — | — | 1 | 7.48 |
| CHEMBL28920 | — | — | 1 | 7.19 |
| CHEMBL28563 | — | — | 1 | 7.19 |
| CHEMBL27732 | — | — | 1 | 7.00 |
| CHEMBL29147 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287169 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL285368 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL28920 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL28563 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL27732 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL29147 | — | IC50 | = | 3400.0 | nM | 5.47 |