Assay Detail
Functional
CHEMBL848481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.22 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305076 | — | — | 1 | 8.68 |
| CHEMBL64507 | — | — | 1 | 8.60 |
| CHEMBL60496 | — | — | 1 | 8.60 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.54 |
| CHEMBL64813 | — | — | 1 | 8.21 |
| CHEMBL60725 | — | — | 1 | 8.04 |
| CHEMBL291543 | — | — | 1 | 8.02 |
| CHEMBL60738 | — | — | 1 | 8.00 |
| CHEMBL62990 | — | — | 1 | 7.92 |
| CHEMBL62920 | — | — | 1 | 7.89 |
| CHEMBL65330 | — | — | 1 | 7.62 |
| CHEMBL64585 | — | — | 1 | 7.52 |
| CHEMBL1908355 | TENIDAP | 2.0 | 1 | 7.28 |
| CHEMBL60793 | — | — | 1 | 7.00 |
| CHEMBL302441 | — | — | 1 | 6.70 |
| CHEMBL62632 | — | — | 1 | 6.62 |
| CHEMBL64759 | — | — | 1 | 6.50 |
| CHEMBL293689 | — | — | 1 | 6.50 |
| CHEMBL64182 | — | — | 1 | 6.47 |
| CHEMBL61731 | — | — | 1 | 6.39 |
| CHEMBL62723 | — | — | 1 | 6.39 |
| CHEMBL62874 | — | — | 1 | 6.16 |
| CHEMBL302155 | — | — | 1 | 6.00 |
| CHEMBL303365 | — | — | 1 | 5.47 |
| CHEMBL64891 | — | — | 1 | 5.36 |
| CHEMBL62439 | — | — | 1 | - |
| CHEMBL303092 | — | — | 1 | - |
| CHEMBL65140 | — | — | 1 | - |
| CHEMBL65325 | — | — | 1 | - |
| CHEMBL294100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305076 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL64507 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL60496 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL64813 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL60725 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL291543 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL60738 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL62990 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL62920 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL65330 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL64585 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1908355 | TENIDAP | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL60793 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL302441 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL62632 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL64759 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL293689 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL64182 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL61731 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL62723 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL62874 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL302155 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL303365 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL64891 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL62439 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL303092 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL65140 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL65325 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL294100 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL304489 | — | IC50 | < | 1.0 | nM | - |