Assay Detail
Binding
CHEMBL852357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Mu opioid receptor of rat brain
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.92 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 9.80 |
| CHEMBL366311 | — | — | 1 | 8.82 |
| CHEMBL408680 | — | — | 1 | 7.94 |
| CHEMBL361033 | — | — | 2 | 7.68 |
| CHEMBL186527 | — | — | 1 | 7.64 |
| CHEMBL361274 | — | — | 1 | 7.26 |
| CHEMBL188558 | — | — | 1 | 7.16 |
| CHEMBL188565 | — | — | 1 | - |
| CHEMBL440380 | — | — | 2 | - |
| CHEMBL362514 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL366311 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL408680 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL361033 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL186527 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL361274 | — | Ki | = | 54.7 | nM | 7.26 |
| CHEMBL188558 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL361033 | — | Ki | = | 85.6 | nM | 7.07 |
| CHEMBL188565 | — | Ki | > | 100.0 | nM | - |
| CHEMBL440380 | — | Ki | > | 100.0 | nM | - |
| CHEMBL362514 | — | Ki | > | 100.0 | nM | - |
| CHEMBL440380 | — | Ki | > | 100.0 | nM | - |
| CHEMBL362514 | — | Ki | > | 100.0 | nM | - |