Assay Detail
Binding
CHEMBL853018
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Binding affinity to recombinant human adenosine A1 receptor
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pKi | 17 | - | - |
| Ki | 14 | 7.41 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382135 | — | — | 1 | 8.37 |
| CHEMBL199611 | — | — | 1 | 8.11 |
| CHEMBL372148 | — | — | 1 | 7.96 |
| CHEMBL199446 | — | — | 1 | 7.83 |
| CHEMBL16929 | — | — | 1 | 7.74 |
| CHEMBL370378 | — | — | 1 | 7.74 |
| CHEMBL201750 | — | — | 1 | 7.49 |
| CHEMBL16677 | — | — | 1 | 7.39 |
| CHEMBL275427 | — | — | 1 | 7.30 |
| CHEMBL275605 | — | — | 1 | 7.20 |
| CHEMBL17003 | — | — | 1 | 7.13 |
| CHEMBL201721 | — | — | 1 | 6.62 |
| CHEMBL278039 | — | — | 1 | 6.53 |
| CHEMBL273807 | — | — | 1 | 6.39 |
| CHEMBL199717 | — | — | 1 | - |
| CHEMBL201003 | — | — | 1 | - |
| CHEMBL197606 | — | — | 1 | - |
| CHEMBL199808 | — | — | 1 | - |
| CHEMBL203208 | — | — | 1 | - |
| CHEMBL199856 | — | — | 1 | - |
| CHEMBL201608 | — | — | 1 | - |
| CHEMBL203467 | — | — | 1 | - |
| CHEMBL201217 | — | — | 1 | - |
| CHEMBL201228 | — | — | 1 | - |
| CHEMBL201591 | — | — | 1 | - |
| CHEMBL381747 | — | — | 1 | - |
| CHEMBL201578 | — | — | 1 | - |
| CHEMBL201536 | — | — | 1 | - |
| CHEMBL202925 | — | — | 1 | - |
| CHEMBL383031 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382135 | — | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL199611 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL372148 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL199446 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL16929 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL370378 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL201750 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL16677 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL275427 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL275605 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL17003 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL201721 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL278039 | — | Ki | = | 295.12 | nM | 6.53 |
| CHEMBL273807 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL199910 | — | pKi | - | — | - | |
| CHEMBL199717 | — | pKi | - | — | - | |
| CHEMBL201003 | — | pKi | - | — | - | |
| CHEMBL197606 | — | pKi | - | — | - | |
| CHEMBL199808 | — | pKi | - | — | - | |
| CHEMBL203208 | — | pKi | - | — | - | |
| CHEMBL199856 | — | pKi | - | — | - | |
| CHEMBL201608 | — | pKi | - | — | - | |
| CHEMBL203467 | — | pKi | - | — | - | |
| CHEMBL201217 | — | pKi | - | — | - | |
| CHEMBL201228 | — | pKi | - | — | - | |
| CHEMBL201591 | — | pKi | - | — | - | |
| CHEMBL381747 | — | pKi | - | — | - | |
| CHEMBL201578 | — | pKi | - | — | - | |
| CHEMBL201536 | — | pKi | - | — | - | |
| CHEMBL202925 | — | pKi | - | — | - | |
| CHEMBL383031 | — | pKi | - | — | - |