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Assay Detail

CHEMBL853089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Melanin-concentrating hormone receptor 1 (CHEMBL344)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts.
Ulven T, Little PB, Receveur JM, Frimurer TM, Rist O, Nørregaard PK, Högberg T.
Bioorg Med Chem Lett (2006) 16 : 1070 -1075
PubMed 16289819 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 8.26 9.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL425407 1 9.04
CHEMBL204952 1 8.89
CHEMBL205111 1 8.77
CHEMBL436320 1 8.70
CHEMBL379693 1 8.64
CHEMBL184084 1 8.64
CHEMBL204428 1 8.62
CHEMBL203586 1 8.49
CHEMBL2113218 1 8.47
CHEMBL202095 1 8.43
CHEMBL203558 1 8.43
CHEMBL204801 1 8.39
CHEMBL203699 1 8.33
CHEMBL379886 1 8.28
CHEMBL442794 1 8.24
CHEMBL382161 1 8.15
CHEMBL202854 1 8.00
CHEMBL204082 1 7.89
CHEMBL204968 1 7.85
CHEMBL189118 1 7.80
CHEMBL202563 1 7.77
CHEMBL203544 1 7.64
CHEMBL205115 1 7.48
CHEMBL203161 1 7.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL425407 IC50 = 0.91 nM 9.04
CHEMBL204952 IC50 = 1.3 nM 8.89
CHEMBL205111 IC50 = 1.7 nM 8.77
CHEMBL436320 IC50 = 2.0 nM 8.70
CHEMBL379693 IC50 = 2.3 nM 8.64
CHEMBL184084 IC50 = 2.3 nM 8.64
CHEMBL204428 IC50 = 2.4 nM 8.62
CHEMBL203586 IC50 = 3.2 nM 8.49
CHEMBL2113218 IC50 = 3.4 nM 8.47
CHEMBL202095 IC50 = 3.7 nM 8.43
CHEMBL203558 IC50 = 3.7 nM 8.43
CHEMBL204801 IC50 = 4.1 nM 8.39
CHEMBL203699 IC50 = 4.7 nM 8.33
CHEMBL379886 IC50 = 5.3 nM 8.28
CHEMBL442794 IC50 = 5.7 nM 8.24
CHEMBL382161 IC50 = 7.1 nM 8.15
CHEMBL202854 IC50 = 10.0 nM 8.00
CHEMBL204082 IC50 = 13.0 nM 7.89
CHEMBL204968 IC50 = 14.0 nM 7.85
CHEMBL189118 IC50 = 16.0 nM 7.80
CHEMBL202563 IC50 = 17.0 nM 7.77
CHEMBL203544 IC50 = 23.0 nM 7.64
CHEMBL205115 IC50 = 33.0 nM 7.48
CHEMBL203161 IC50 = 44.0 nM 7.36