Compound Detail
CHEMBL205115
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Basic Information
| ChEMBL ID | CHEMBL205115 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HUINMAHGYCSHAO-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
426.9
MW (Da)
4.21
ALogP
5
HBA
1
HBD
57.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 7.48 | 6.8833 | 33.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 33.0 | nM | 7.48 | Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC a... | 16289819 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 83.0 | nM | 7.08 | Inhibition of human MCH1 receptor by SPA assay | 16289819 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 807.0 | nM | 6.09 | Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell ... | 16289819 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16289819 | 10.1016/j.bmcl.2005.10.066 | Melanin-concentrating hormone receptor 1 | 3 |
Data from ChEMBL 36 via Core Engine