Assay Detail
Binding
CHEMBL853090
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Inhibition of human MCH1 receptor by SPA assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.10 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205111 | — | — | 1 | 8.30 |
| CHEMBL425407 | — | — | 1 | 8.28 |
| CHEMBL204428 | — | — | 1 | 8.21 |
| CHEMBL204952 | — | — | 1 | 8.02 |
| CHEMBL436320 | — | — | 1 | 7.92 |
| CHEMBL203558 | — | — | 1 | 7.89 |
| CHEMBL203586 | — | — | 1 | 7.82 |
| CHEMBL203699 | — | — | 1 | 7.80 |
| CHEMBL379886 | — | — | 1 | 7.75 |
| CHEMBL379693 | — | — | 1 | 7.75 |
| CHEMBL204801 | — | — | 1 | 7.75 |
| CHEMBL189118 | — | — | 1 | 7.72 |
| CHEMBL2113218 | — | — | 1 | 7.70 |
| CHEMBL202095 | — | — | 1 | 7.70 |
| CHEMBL382161 | — | — | 1 | 7.66 |
| CHEMBL184084 | — | — | 1 | 7.54 |
| CHEMBL204082 | — | — | 1 | 7.40 |
| CHEMBL204968 | — | — | 1 | 7.40 |
| CHEMBL442794 | — | — | 1 | 7.38 |
| CHEMBL202563 | — | — | 1 | 7.32 |
| CHEMBL202854 | — | — | 1 | 7.20 |
| CHEMBL205115 | — | — | 1 | 7.08 |
| CHEMBL203161 | — | — | 1 | 7.06 |
| CHEMBL204912 | — | — | 1 | 6.98 |
| CHEMBL203804 | — | — | 1 | 6.90 |
| CHEMBL382126 | — | — | 1 | 6.79 |
| CHEMBL203549 | — | — | 1 | 6.68 |
| CHEMBL204798 | — | — | 1 | 6.57 |
| CHEMBL203544 | — | — | 1 | 6.37 |
| CHEMBL204168 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205111 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL425407 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL204428 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL204952 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL436320 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL203558 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL203586 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL203699 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL379886 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL379693 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204801 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL189118 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2113218 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL202095 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL382161 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL184084 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL204082 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL204968 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL442794 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL202563 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL202854 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL205115 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL203161 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL204912 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL203804 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL382126 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL203549 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL204798 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL203544 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL204168 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL205112 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL201813 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL381143 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL203929 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL203858 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL203917 | — | IC50 | = | 9460.0 | nM | 5.02 |
| CHEMBL203820 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL426481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL203504 | — | IC50 | > | 10000.0 | nM | - |