Assay Detail
Binding
CHEMBL853627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.96 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204952 | — | — | 1 | 7.80 |
| CHEMBL205111 | — | — | 1 | 7.64 |
| CHEMBL442794 | — | — | 1 | 7.60 |
| CHEMBL184084 | — | — | 1 | 7.60 |
| CHEMBL379693 | — | — | 1 | 7.51 |
| CHEMBL425407 | — | — | 1 | 7.48 |
| CHEMBL436320 | — | — | 1 | 7.15 |
| CHEMBL204428 | — | — | 1 | 7.09 |
| CHEMBL204082 | — | — | 1 | 7.04 |
| CHEMBL204801 | — | — | 1 | 7.00 |
| CHEMBL189118 | — | — | 1 | 6.84 |
| CHEMBL203699 | — | — | 1 | 6.72 |
| CHEMBL202095 | — | — | 1 | 6.61 |
| CHEMBL203544 | — | — | 1 | 6.41 |
| CHEMBL202563 | — | — | 1 | 6.32 |
| CHEMBL202854 | — | — | 1 | 6.32 |
| CHEMBL204968 | — | — | 1 | 6.14 |
| CHEMBL205115 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204952 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL205111 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL442794 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL184084 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL379693 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL425407 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL436320 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL204428 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL204082 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL204801 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL189118 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL203699 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL202095 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL203544 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL202563 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL202854 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL204968 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL205115 | — | IC50 | = | 807.0 | nM | 6.09 |