Assay Detail
Binding
CHEMBL853224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 11betaHSD2 transfected in intact HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.91 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425772 | — | — | 1 | 5.22 |
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | 5.19 |
| CHEMBL382614 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425772 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL382614 | — | IC50 | = | 48000.0 | nM | 4.32 |