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Assay Detail

CHEMBL853398

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Binding
Inhibition of GST P1-1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Glutathione S-transferase P (CHEMBL3902)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bivalent inhibitors of glutathione S-transferase: the effect of spacer length on isozyme selectivity.
Maeda DY, Mahajan SS, Atkins WM, Zebala JA.
Bioorg Med Chem Lett (2006) 16 : 3780 -3783
PubMed 16675217 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.25 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379437 1 7.51
CHEMBL209755 1 7.34
CHEMBL216505 1 6.85
CHEMBL211916 1 6.21
CHEMBL212685 1 6.15
CHEMBL212097 1 6.00
CHEMBL211727 1 5.99
CHEMBL456 ETHACRYNIC ACID 4.0 1 5.40
CHEMBL212517 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379437 IC50 = 31.0 nM 7.51
CHEMBL209755 IC50 = 46.1 nM 7.34
CHEMBL216505 IC50 = 142.0 nM 6.85
CHEMBL211916 IC50 = 624.0 nM 6.21
CHEMBL212685 IC50 = 704.0 nM 6.15
CHEMBL212097 IC50 = 992.4 nM 6.00
CHEMBL211727 IC50 = 1022.0 nM 5.99
CHEMBL456 ETHACRYNIC ACID IC50 = 4000.0 nM 5.40
CHEMBL212517 IC50 = 15046.0 nM 4.82