Assay Detail
Binding
CHEMBL853454
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Inhibition of human cathepsin K
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.61 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212907 | — | — | 1 | 9.10 |
| CHEMBL213930 | — | — | 1 | 8.89 |
| CHEMBL212879 | — | — | 1 | 8.89 |
| CHEMBL213244 | — | — | 1 | 8.52 |
| CHEMBL211737 | — | — | 1 | 8.46 |
| CHEMBL213194 | — | — | 1 | 8.32 |
| CHEMBL184514 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212907 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL213930 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL212879 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL213244 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL211737 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL213194 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL184514 | — | Ki | = | 8.0 | nM | 8.10 |