Assay Detail
Binding
CHEMBL853499
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Inhibition of Jak3 by HTRF kinase assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.57 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215019 | — | — | 1 | 7.80 |
| CHEMBL212964 | — | — | 1 | 7.80 |
| CHEMBL385937 | — | — | 1 | 7.70 |
| CHEMBL215863 | — | — | 1 | 7.34 |
| CHEMBL215943 | — | — | 1 | 7.14 |
| CHEMBL212183 | — | — | 1 | 6.97 |
| CHEMBL215969 | — | — | 1 | 6.88 |
| CHEMBL212128 | — | — | 1 | 6.81 |
| CHEMBL385055 | — | — | 1 | 6.71 |
| CHEMBL214495 | — | — | 1 | 6.60 |
| CHEMBL212181 | — | — | 1 | 6.48 |
| CHEMBL215813 | — | — | 1 | 6.25 |
| CHEMBL213290 | — | — | 1 | 6.20 |
| CHEMBL213831 | — | — | 1 | 6.14 |
| CHEMBL386661 | — | — | 1 | 6.06 |
| CHEMBL385598 | — | — | 1 | 6.01 |
| CHEMBL424719 | — | — | 1 | 5.94 |
| CHEMBL427233 | — | — | 1 | 5.87 |
| CHEMBL214530 | — | — | 1 | 5.66 |
| CHEMBL215952 | — | — | 1 | 5.01 |
| CHEMBL213478 | — | — | 1 | - |
| CHEMBL212953 | — | — | 1 | - |
| CHEMBL212195 | — | — | 1 | - |
| CHEMBL384942 | — | — | 1 | - |
| CHEMBL214556 | — | — | 1 | - |
| CHEMBL427226 | — | — | 1 | - |
| CHEMBL215691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215019 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL212964 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL385937 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL215863 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL215943 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL212183 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL215969 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL212128 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL385055 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL214495 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL212181 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL215813 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL213290 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL213831 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL386661 | — | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL385598 | — | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL424719 | — | IC50 | = | 1141.0 | nM | 5.94 |
| CHEMBL427233 | — | IC50 | = | 1339.0 | nM | 5.87 |
| CHEMBL214530 | — | IC50 | = | 2189.0 | nM | 5.66 |
| CHEMBL215952 | — | IC50 | = | 9819.0 | nM | 5.01 |
| CHEMBL213478 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL212953 | — | IC50 | > | 8333.0 | nM | - |
| CHEMBL212195 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL384942 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL214556 | — | IC50 | > | 8333.0 | nM | - |
| CHEMBL427226 | — | IC50 | > | 8333.0 | nM | - |
| CHEMBL215691 | — | IC50 | > | 8333.0 | nM | - |