Assay Detail
Functional
CHEMBL853657
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Antiproliferative activity against Leishmania donovani DI700 promastigotes overproducing ADOMETDC enzyme
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222838 | EFLORNITHINE, (S)- | 2.0 | 1 | 4.52 |
| CHEMBL216913 | MITOGUAZONE | 3.0 | 1 | - |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL13968 | BUTYLAMINE | — | 1 | - |
| CHEMBL381751 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222838 | EFLORNITHINE, (S)- | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL216913 | MITOGUAZONE | EC50 | = | 1500000.0 | nM | - |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 9700000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 1700000.0 | nM | - |
| CHEMBL13968 | BUTYLAMINE | EC50 | = | 200000.0 | nM | - |
| CHEMBL381751 | — | EC50 | > | 10000000.0 | nM | - |