Assay Detail
Functional
CHEMBL853685
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Vasorelaxation activity on KCl-induced contractile tone in Wistar rat thoracic aortic ring
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.25 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 7.01 |
| CHEMBL426354 | — | — | 1 | 5.62 |
| CHEMBL438826 | — | — | 1 | 5.22 |
| CHEMBL373445 | — | — | 1 | 5.14 |
| CHEMBL219504 | — | — | 1 | 4.88 |
| CHEMBL373421 | — | — | 1 | 4.82 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.72 |
| CHEMBL374085 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | IC50 | = | 97.72 | nM | 7.01 |
| CHEMBL426354 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL438826 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL373445 | — | IC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL219504 | — | IC50 | = | 13182.57 | nM | 4.88 |
| CHEMBL373421 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL374085 | — | IC50 | = | 25118.86 | nM | 4.60 |