Assay Detail
Functional
CHEMBL853822
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Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human gammaherpesvirus 4 |
| Cell Type | Daudi |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.26 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.48 |
| CHEMBL384008 | — | — | 1 | 4.04 |
| CHEMBL218614 | — | — | 1 | - |
| CHEMBL384959 | — | — | 1 | - |
| CHEMBL425798 | — | — | 1 | - |
| CHEMBL217219 | — | — | 1 | - |
| CHEMBL384629 | — | — | 1 | - |
| CHEMBL383977 | — | — | 1 | - |
| CHEMBL386690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL384008 | — | EC50 | = | 91600.0 | nM | 4.04 |
| CHEMBL218614 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL384959 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL425798 | — | EC50 | < | 30.0 | nM | - |
| CHEMBL217219 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL384629 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL383977 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL386690 | — | EC50 | > | 50000.0 | nM | - |