Assay Detail
Functional
CHEMBL853827
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Inhibition of VZV replication in HFF cells by plaque reduction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.53 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218614 | — | — | 1 | 5.23 |
| CHEMBL217219 | — | — | 1 | 4.47 |
| CHEMBL386690 | — | — | 1 | 4.26 |
| CHEMBL384629 | — | — | 1 | 4.17 |
| CHEMBL383977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218614 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL217219 | — | EC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL386690 | — | EC50 | = | 54600.0 | nM | 4.26 |
| CHEMBL384629 | — | EC50 | = | 68300.0 | nM | 4.17 |
| CHEMBL383977 | — | EC50 | > | 100000.0 | nM | - |